Sunday, 19 June 2016

Antibiotics for Streptococcus viridans



Classification of Streptococci

Lancefield Group
Species
Hemolysis
Associated Diseases
Treatment
Lancefield Group
Species
Hemolysis
Associated Diseases
Treatment
A
S. pyogenes
β
Pharyngitis, tonsillitis, wound and skin infections, septicemia, scarlet fever, pneumonia, rheumatic fever, glomerulonephritis
Penicillin, erythromycin, clindamycin
Necrotizing fasciitis
Expeditious surgical management
β-Lactam (usually broad spectrum until etiology is identified; if GABHS is confirmed, penicillin or cefazolin can be used) plus clindamycin
B
S. agalactiae
β
Sepsis, postpartum or neonatal sepsis, meningitis, skin infections, endocarditis, septic arthritis, UTIs
Penicillin or ampicillin, cephalosporin, vancomycin
C and G
S. equi, S. canis
β
Pharyngitis, pneumonia, cellulitis, pyoderma, erysipelas, impetigo, wound infections, puerperal sepsis, neonatal sepsis, endocarditis, septic arthritis
Penicillin, vancomycin, cephalosporins, macrolides (variable susceptibility)
D
Enterococcal: Enterococcus faecalis, E. faecium
Nonenterococcal: S. bovis, S. equinus
α or γ
Endocarditis, UTI, intra-abdominal infection, cellulitis, wound infection as well as concurrent bacteremia
Penicillin, ampicillin, vancomycin (plus an aminoglycoside for serious infection)
Vancomycin-resistant enterococci: Streptogramins (quinupristin/dalfopristin), oxazolidinones (linezolid), lipopeptide (daptomycin)
S. gallolyticus (formerly S. bovis biotype I)
Colonic adenomas or carcinomas
Viridans*
S. mutans, S. sanguis, S. salivarius, S. mitior, S. milleri
α or γ
Endocarditis, bacteremia, meningitis, localized infection, abscesses (particularly S. milleri)
Penicillin, ampicillin, vancomycin (plus an aminoglycoside for serious infection), other antibiotics based on in vitro susceptibility
S. suis
Meningitis, sometimes toxic shock syndrome
S. iniae
Cellulitis, invasive infections from fish
Penicillin
*Do not conform to specific serogroups.
GABHS = group A β-hemolytic streptococci.

Source: http://www.merckmanuals.com/professional/infectious-diseases/gram-positive-cocci/streptococcal-infections

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